Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-04466 |
STK40 Protein, Human, Recombinant (His & GST)
SHIK,SgK495,serine/threonine kinase 40 |
Human | Baculovirus Insect Cells |
STK40 is localized to both the cytoplasm and the nucleus. It is ubiquitously expressed. Mechanistically, Stk40 interacts with Rcn2, which also activates Erk1/2 to induce ExEn specification in mouse ESCs. Stk40 is able to activate the Erk/MAPK pathway and induce extraembryonic-endoderm (ExEn) differentiation in mouse ESCs. Interestingly, cells overexpressing Stk40 exclusively contribute to the ExEn layer of chimeric embryos when injected into host blastocysts. In contrast, deletion of Stk40 in ES... |