Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-01253 |
Serpin A3N Protein, Mouse, Recombinant (His)
Serpina3n,Serine protease inhibitor A3... |
Mouse | HEK293 Cells |
Serine protease inhibitor A3N(Serpin A3N) is a serine protease inhibitor that is structurally related to α1 antichymotrypsin encoded by the SERPINA3 gene. Serpin A3N is highly expressed in brain, testis, lung, thymus, and spleen. It is expressed with low levels in bone marrow, kidney and skeletal muscle. Serpin A3N secreted by Sertoli cells may regulate the activity of locally produced Granzyme B. Granzyme B inhibition by Serpin A3N may therefore regulate Granzyme Bmediated killing by cytotoxic ... | |||
TMPY-04934 |
Serpin A3n Protein, Rat, Recombinant (His)
serine (or cysteine) peptidase inhibitor, clade A, member |
Rat | HEK293 Cells |
Serpina3n may represent a circulating biomarker of muscle atrophy associated with GC and, broadly, a reflection of dynamic changes in muscle mass. Serpina3n blocks endogenous increases in the activity of select skeletal muscle resident proteases during injury or dystrophic disease, which stabilizes the sarcolemma leading to less myofiber degeneration and increased regeneration. |