Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-04671 |
MCP-5 Protein, Mouse, Recombinant (His)
chemokine (C-C motif) ligand 12,MCP-5,Scya... |
Mouse | P. pastoris (Yeast) |
Ccl12 prevented initiation of the reparative response by prolonging inflammation and inhibiting fibroblast conversion to myofibroblasts, resulting in diminished scar formation. Macrophage secretion of Ccl12 directly impaired fibronectin and collagen deposition and indirectly stimulated collagen degradation through upregulation of matrix metalloproteinase-2. In post-MI patients, circulating LPS levels strongly associated with the Ccl12 homologue monocyte chemotactic protein 1 (MCP-1). Both MCP-1 ... |