Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T61043 | STING agonist-7 | ||
STING agonist-7 是一种非核苷酸STING 的激动剂,可选择性结合小鼠而非人类 STING。 | |||
T69888 |
SB02024
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SB02024 is a VPS34 inhibitor. SB02024 activates cGAS-STING signaling and sensitizes tumors to STING agonist. SB02024 blocked autophagy in vitro and reduced xenograft growth of two breast cancer cell lines, MDA-MB-231 and MCF-7, in vivo. Vps34 inhibitor significantly potentiated cytotoxicity of Sunitinib and Erlotinib in MCF-7 and MDA-MB-231 in vitro in monolayer cultures and when grown as multicellular spheroids. Our data suggests that inhibition of autophagy significantly improves sensitivity... |