Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T38162 | STING18 | ||
STING18 is a competitive ligand of stimulator of interferon genes (STING; IC50 = 0.068 μM in a radioligand binding assay).1 It inhibits cGAMP-induced IFN-β production (IC50 = 11 μM) but does not stimulate IFN-β production (EC50 = >30 μM) in THP-1 cells. |1. Siu, T., Altman, M.D., Baltus, G.A., et al. Discovery of a novel cGAMP competitive ligand of the inactive form of STING. Med. Chem. Lett. 10(1), 92-97 (2019). | |||
T81084 |
STING agonist-18
|
||
STINGagonist-18(compound 1a)适用于ADCs的合成,例如与Trastuzumab偶联。 | |||
T63458 |
STING agonist-11
|
||
STING agonist-11 是一种 STING 小分子环脲类的有效激活剂 (EC50: 18 nM)。STING 激活是一种具有高度潜力的免疫疗法。 | |||
T37832 |
CAY10761
CAY10761 |
||
CAY10761 is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1; IC50s = 467 and 429 μM for the human and snake venom enzymes, respectively).1,2 It also inhibits mushroom tyrosinase (Ki = 1.9 μM) and urease from jack bean, P. mirabilis, and B. pasteurii (IC50s = 0.093, <0.125, and 0.089 mM, respectively, at pH 8.2).3,4 |1. Khan, K.M., Fatima, N., Rasheed, M., et al. 1,3,4-Oxadiazole-2(3H)-thione and its analogues: A new class of non-competitive nucleotide pyrophosphatases/p... |