Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6741 |
SPDP
SPDP Crosslinker |
Others | Others |
SPDP 是一种短链交联剂,用于通过 NHS 酯和吡啶基二硫醇反应基团与半胱氨酸巯基形成可切割(可还原)的二硫键,实现胺与巯基的共轭。它是一种可降解的 ADC 连接剂,可用于合成抗体偶联药物。 | |||
T33904 |
PDPH Crosslinker
PDPH Cross linker,SPDP Hydrazide,PDPH Cross-linker |
||
PDPH crosslinker(SPDP Hydrazide) is a lytic heterobisfunctional protein crosslinker. | |||
T18725 |
Sulfo-LC-SPDP
|
Others | Others |
Sulfo-LC-SPDP is a heterobifunctional crosslinker characterized by its thiol-cleavable and membrane impermeable properties. | |||
T17834 |
DM4-SPDP
|
Others | Others |
DM4-SPDP, a drug-linker conjugate, integrates the antitubulin agent DM4 with the linker SMCC, facilitating the creation of antibody drug conjugates[1]. Additionally, SPDP serves as a short-chain crosslinker enabling amine-to-sulfhydryl conjugation, leveraging NHS-ester and pyridyldithiol groups to establish cleavable (reducible) disulfide bonds with cysteine sulfhydryls[2][3]. |