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抑制剂 & 化合物

1

天然产物

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Cat. No. Product Name Target Signaling Pathways
T7263 SMS2-IN-2

SMS2 inhibitors

Others Others
SMS2-IN-2 (SMS2 inhibitors) 是一种具有高度选择性、口服具有活力的鞘磷脂合成酶 2 抑制剂,能够作用于 SMS2 (IC50:100 nM)和 SMS1 (IC50:56 nM)。它可减轻慢性炎症反应。
T12938 SMS2-IN-1

Others Others
SMS2-IN-1 是一种有效且具有高选择性的鞘磷脂合成酶 2 (SMS2) 抑制剂, IC50 为 6.5 nM,Kd 为 37 nM。SMS2-IN-1 对 SMS2 的选择性比 SMS1 (IC50 为 1000 nM) 多 150 倍。
T2584 Octreotide

SMS 201-995,奥曲肽

Somatostatin GPCR/G Protein
Octreotide (SMS 201-995) 是一种有效的生长激素、胰高血糖素和胰岛素抑制剂。它主要与生长抑素 2、3 和 5 亚型受体结合,可增强 Gi 活性,降低胞内 cAMP 的产生。
T37953 Sphingomyelins (buttermilk)

Sphingomyelins (SMs) are bioactive sphingolipids found in mammalian cell membranes.1SMs make up 2-15% of the total organ phospholipid population but are found at higher concentrations in the brain and myelin sheaths surrounding peripheral nerves. They interact with cholesterol to control its distribution within cellular membranes and maintain cholesterol homeostasis in cells. SMs undergo hydrolysis by sphingomyelinase to form ceramides, which are sphingolipid mediators of intracellular signaling...

化合物

SMS2-IN-2
Cat.No: T7263
Synonym: SMS2 inhibitors
Target: Others
SMS2-IN-1
Cat.No: T12938
Synonym:
Target: Others
Octreotide
Cat.No: T2584
Synonym: SMS 201-995,奥曲肽
Target: Somatostatin
Sphingomyelins (buttermilk)
Cat.No: T37953
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
TN6772 Malabaricone C

Others Others
Malabaricone C 是天然的鞘磷脂合成酶抑制剂,对 SMS 1 和 SMS 2 的IC50分别为 3 和 1.5 μM。

天然产物

Malabaricone C
Cat.No: TN6772
Synonym:
Target: Others
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