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Cat. No. Product Name Target Signaling Pathways
T69596 SK-575

PROTACs PROTAC
SK-575 is a Highly Potent and Efficacious Proteolysis-Targeting Chimera Degrader of PARP1 for Treating Cancers. SK-575 potently inhibits the growth of cancer cells bearing BRCA1/2 mutations and induces potent and specific degradation of PARP1 in various human cancer cells even at low picomolar concentrations. SK-575 achieves durable tumor growth inhibition in mice when used as a single agent or in combination with cytotoxic agents, such as temozolomide and cisplatin.
T74558 SK-575-NEG

SK-575-NEG(化合物28)是SK-575的甲基化对应物,通过对SK-575中的哌啶-2,6-二酮氨基进行甲基化合成而得,用作对照化合物。SK-575-NEG强效结合PARP1,IC50值仅为2.64 nM。在1 μM浓度下,SK-575-NEG对MDA-MB-436和Capan-1细胞中PARP1的降解完全无效。

化合物

SK-575
Cat.No: T69596
Synonym:
Target: PROTACs
SK-575-NEG
Cat.No: T74558
Synonym:
Target:
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