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Cat. No. | Product Name | Target | Signaling Pathways |
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T76869 |
Lirentelimab
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Lirentelimab (AK002) 是一种人源化IgG1单克隆抗体,目标为唾液酸结合Ig样凝集素8 (SIGLEC8)。该化合物通过诱导IL-5激活的嗜酸性粒细胞细胞凋亡并抑制IL-5介导的肥大细胞激活,用于嗜酸性胃炎、十二指肠炎的研究。 |
Cat. No. | Product Name | Species | Expression System |
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TMPK-01212 |
Siglec-8 Protein, Human, Recombinant (His & Avi), Biotinylated
SIGLEC8,CDw329,SAF2SAF-2,SAF2,SIGLEC |
Human | HEK293 Cells |
Siglec-8, also known as SAF, is an approximately 75 kDa transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-8 consists of a 347 amino acid (aa) extracellular domain (ECD) with three Ig-like domains.Putative adhesion molecule that mediates sialic-acid dependent binding to red blood cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. Siglec-8 Protein, Human, Recombinant (His & A... | |||
TMPK-01211 |
Siglec-8 Protein, Human, Recombinant (His & Avi)
SIGLEC8,SAF2SAF-2,SAF2,CDw329,Siglec |
Human | HEK293 Cells |
Siglec-8, also known as SAF, is an approximately 75 kDa transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-8 consists of a 347 amino acid (aa) extracellular domain (ECD) with three Ig-like domains.Putative adhesion molecule that mediates sialic-acid dependent binding to red blood cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. Siglec-8 Protein, Human, Recombinant (His & A... | |||
TMPJ-01359 |
Siglec-8 Protein, Human, Recombinant (hFc)
SAF2,CD329 antigen,CDw329,Siglec-8,SAF2SAF... |
Human | HEK293 Cells |
Siglec-8 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 80-100 KDa and the accession number is Q9NYZ4. | |||
TMPJ-01361 |
Siglec-8 Protein, Human, Recombinant (mFc)
CD329 antigen,Siglec-8,SAF2SAF-2,CDw329, |
Human | HEK293 Cells |
Siglec-8 is also known as SIGLEC8, SAF2, SIGLEC-8, SIGLEC8L and sialic acid binding Ig like lectin 8, is an approximately 75 kDa transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Siglec-8 is expressed on eosinophils, basophils, and mast cells, and it shows a binding preference for the carbohydrate 6-O sulfated sLex. At the tissue level, Siglec-8 mRNA was found to be most highly expressed in lung, PBMCs, spleen, and kidney. Mature human Siglec-8 c... | |||
TMPJ-01360 |
Siglec-8 Protein, Human, Recombinant (His)
Siglec8,SAF-2,SAF2SAF-2,Siglec- |
Human | HEK293 Cells |
Siglec-8 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 40-60 KDa and the accession number is Q9NYZ4. | |||
TMPJ-01254 |
Siglec-F Protein, Mouse, Recombinant (His)
sialic acid binding Ig like lectin 8,SAF2,SIGLE... |
Mouse | HEK293 Cells |
Siglec 5 to 11 share a high degree of sequence similarity with CD33/Siglec-3 both in their extracellular and intracellular regions. They are collectively referred to as CD33-related Siglecs. One remarkable feature of the CD33-related Siglecs is their differential expression pattern within the hematopoietic system. This fact, together with the presence of two conserved immunoreceptor tyrosine-based inhibition motifs (ITIMs) in their cytoplasmic tails, suggests that CD33-related Siglecs are involv... |