Cat. No. | Product Name | Target | Signaling Pathways |
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T36536 |
SH-42
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SH-42 is an inhibitor of 24-dehydrocholesterol reductase (DHCR24; IC50= 4.2 nM).1It increases serum levels of desmosterol , the immediate precursor of cholesterol in the Bloch pathway, in mice when administered at a dose of 0.5 mg/animal per day. SH-42 increases levels of arachidonic acid and its metabolite prostaglandin E2, as well as docosahexaenoic acid and its metabolites 19,20-EpDPA and 19,20-DiHDPA, in the peritoneal lavage fluid in a mouse model of peritonitis induced by zymosan A .2 | |||
T64137 |
AChE/BuChE-IN-3
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AChE/BuChE-IN-3 是一种有效的、能够透过血脑屏障的 AChE (IC50: 0.65 μM) 与 BuChE (IC50: 5.77 μM) 抑制剂,对 Aβ1-42 的聚集也表现出抑制作用。AChE/BuChE-IN-3 表现出有效的神经保护活性,对 SH-SY5Y 细胞几乎没有毒性。AChE/BuChE-IN-3 能够用于研究阿尔兹海默症。 |