Cat. No. | Product Name | Target | Signaling Pathways |
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T69832 | RPR203494 | ||
RPR203494 is a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency. | |||
T69831 |
RPR-200765A Mesylayte
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RPR-200765A is a potent and selective inhibitor of p38 MAP kinase (IC50 = 50 nM). It inhibits LPS-stimulated TNFalpha release both in vitro, from human monocytes (EC50 = 110 nM), and in vivo in Balb/c mice (ED50 = 6 mg/kg). At oral doses between 10 and 30 mg/kg/day it reduces the incidence and progression in the rat streptococcal cell wall (SCW) arthritis model when administered in either prophylactic or therapeutic dosing regimens. The compound, which is a mesylate salt and exists as a stable m... |