Cat. No. | Product Name | Target | Signaling Pathways |
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T79517 | ROS inducer 2 | Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
ROS inducer 2 (Compound I16) 是一种经体外测试显示具有良好活性的活性氧诱导剂,其EC50值为3.43 μg/mL。在体内实验中,该化合物对Xanthomonas axonopodis pv. citri表现出优异的生物活性,可以作为研究难治性植物细菌性疾病的杀菌剂。 | |||
T36514 |
QD-394
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QD-394 is an inducer of reactive oxygen species (ROS) production.1It induces lipid peroxidation, increases in intracellular accumulation of reactive oxygen species (ROS), and decreases in the reduced glutathione (GSH) to oxidized GSH (GSSG) ratio in MIA PaCa-2 pancreatic cancer cells when used at concentrations ranging from 0.5 to 10 μM. QD-394 is cytotoxic to MIA PaCa-2, PANC-1, and BxPC-3 cancer cells (IC50s = 0.64, 0.34, and 0.9 μM, respectively). QD-394 acts synergistically with napabucasin ... | |||
T36882 |
CAY10773
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CAY10773 is a derivative of the ferroptosis inducer sorafenib .1It selectively inhibits proliferation of BEL-7402, MGC803, and T24 bladder cancer cells (IC50s = 5.77, 5.21 and 3.97 μM, respectively) over non-cancerous HCV-29 cells (IC50= 23.19 μM). CAY10773 induces apoptosis in T24 cells when used at concentrations ranging from 2 to 6 μM but induces ferroptosis at concentrations greater than or equal to 6 μM with 10 hour or longer incubation times. It increases the production of reactive oxygen ... |