Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T71000 |
RO-5328673
|
||
RO-5328673 is a dual NK2/NK3 antagonist. O5328673. [(3)H]RO5328673 bound to a single saturable site on hNK2, hNK3 and gpNK3 with high-affinity. RO5328673 acted as an insurmountable antagonist at both human and guinea-pig NK3 receptors in the [(3)H]IP accumulation assay. In binding kinetic analyses, [(3)H]RO5328673 had fast association and dissociation rates at hNK2 while it had a fast association rate and a remarkably slow dissociation rate at gp and hNK3. In electrophysiological recordings of g... | |||
T70998 | LY-2979165 | ||
LY-2979165 is a metabotropic glutamate receptor agonist prodrug. |