Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T35883 |
RNF5 inhibitor inh-02
RNF5 inhibitor inh-02 |
Others | Others |
RNF5 inhibitor inh-02, a potent E3 ubiquitin ligase RNF5/RMA1 inhibitor, demonstrates significant efficacy in rescuing F508del-CFTR with an EC50 of 2.2 uM in bronchial epithelial cells homozygous for the F508del mutation. This compound is valuable for cystic fibrosis research[1]. |