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Cat. No.	Product Name	Target	Signaling Pathways
T63382	Protease-Activated Receptor-1 antagonist 3
	Protease-Activated Receptor-1 antagonist 3 是蛋白酶激活受体 1protease-activated receptor-1 的有效拮抗剂 (IC50: 7 nM)。Protease-Activated Receptor-1 antagonist 3 与 hERG K+通道表现出结合亲和力 (IC50: 9 μM)。
T62507	Protease-Activated Receptor-1 antagonist 1
	Protease-Activated Receptor-1 antagonist 1 (Compound 13) 是一种蛋白酶激活受体 1 (PAR-1) 拮抗剂，通过 FLIPR 技术得到的 IC50 为 3 nM。Protease-Activated Receptor-1 antagonist 1 能够用于研究血栓性心血管、心肌梗塞和外周动脉疾病。
T36717	RWJ-56110 dihydrochloride
	RWJ-56110 dihydrochloride is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC50=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. RWJ-56110 dihydrochloride inhibits the aggregation of human platelets induced by both SFLLRN-NH2 (IC50=0.16 μM) and thrombin (IC50=0.34 μM), quite selective relative to U46619 . RWJ-56110 dihydrochloride blocks angiogenesis and blocks the formation of new vessels in vivo. RWJ-56110 dihydrochloride induces cell ap...