Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T38410 |
Phosphoramide mustard
|
DNA Alkylation; Drug Metabolite | DNA Damage/DNA Repair; Metabolism |
Phosphoramide mustard 是环磷酰胺的毒性代谢物物,具有抗癌活性且对卵巢具有毒性,可诱导 DNA 损伤。 | |||
T36701 |
Phosphoramide mustard (cyclohexanamine)
|
||
Phosphoramide mustard cyclohexanamine is the major metabolite for Cyclophosphamide , with anticancer activitiy. Phosphoramide mustard cyclohexanamine induces DNA adduct formation in ovarian granulosa cells, induces DNA damage and elicits the ovarian DNA repair response[1][2]. Phosphoramide mustard cyclohexanamine causes cytotoxicity through forming cross-linked DNA adducts which inhibit DNA strand separation during replication[1].Phosphoramide mustard cyclohexanamine destroys rapidly dividing ce... |