Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T16526 |
Phorbol 12,13-dibutyrate
PDBu,Phorbol dibutyrate |
PKC | Chromatin/Epigenetic; Cytoskeletal Signaling |
Phorbol 12,13-dibutyrate is a PKC activator. It also is a potent skin tumor promoter. | |||
T37983 |
GM 1489
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GM 1489 is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with Ki values of 0.002, 0.1, 0.5, 0.2, and 20 μM for MMP-1, MMP-8, MMP-2, MMP-9, and MMP-3, respectively. It reduces 5-aza-2'-deoxycytidine-induced increases in MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, and MMP-14 expression as well as cell invasion in AsPC-1, BxPC-3, Hs766T, MiaPaCa2, and PANC-1 cancer cells. Topical administration of GM 1489 (100 μg) inhibits increases in ear thickness and epidermal hyperplasia induced by phor... |