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Cat. No.	Product Name	Target	Signaling Pathways
T13845	PROTAC PARP1 degrader	Others	Others
	PROTAC PARP1 degrader is a degrader of PARP1 based on the PROTAC technology. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line (IC50 of 6.12 μM).
T13737	iRucaparib-AP6	Others; PROTACs	Others; PROTAC
	iRucaparib-AP6, a non-trapping PARP1 degrader, blocks both the catalytic activity and scaffolding effects of PARP1. iRucaparib-AP6 is a highly efficient and specific PARP1 degrader based on Rucaparib by using the PROTAC approach.
T16317	NH2-PEG7	Others	Others
	NH2-PEG7 is a para-aminomethylbenzyloxycarbonyl (PROTAC) linker compound consisting of a polyethylene glycol (PEG) chain. It finds application in the synthesis of the PROTAC PARP1 degrader called iRucaparib-AP6[1].
T18814	Thalidomide-NH-PEG7	Others	Others
	Thalidomide-NH-PEG7 is a synthesized conjugate of an E3 ligase ligand and linker designed for use in antibody-drug conjugates (ADCs). This compound can be coupled to a protein ligand via a linker to create PROTAC iRucaparib-AP6, an extremely selective degrader of PARP1[1].
T18662	(S,R,S)-AHPC-C2-PEG4-N3 VH032-C2-PEG4-N3	Others	Others
	(S,R,S)-AHPC-C2-PEG4-N3 (VH032-C2-PEG4-N3) is a synthesized E3 ligase ligand-linker conjugate combining the (S,R,S)-AHPC-based VHL ligand with a 4-unit polyethylene glycol (PEG) linker, employed in PROteolysis TAgeting Chimera (PROTAC) technology. This compound facilitates the creation of vRucaparib-TP4, a potent PARP1 degrader demonstrating a half-maximal degrading concentration (DC50) of 82 nM[1].
T39806	Pomalidomide 4'-PEG3-azide Pomalidomide 4'-PEG3-azide
	Pomalidomide 4'-PEG3-azide is a chemically synthesized conjugate consisting of an E3 ligase ligand-linker conjugate that incorporates the cereblon ligand derived from Pomalidomide, along with a linker. This compound, Pomalidomide 4'-PEG3-azide, is utilized in the synthesis of iRucaparib-TP3 (Compound 3). iRucaparib-TP3, developed through the PROTAC strategy, is an effective degrader of PARP1, derived from Rucaparib.

化合物

PROTAC PARP1 degrader

Cat.No: T13845

Target: Others

Cat.No: T13737

Target: Others, PROTACs

Cat.No: T16317

Target: Others

Thalidomide-NH-PEG7

Cat.No: T18814

Target: Others

(S,R,S)-AHPC-C2-PEG4-N3

Cat.No: T18662

Synonym: VH032-C2-PEG4-N3

Target: Others

Pomalidomide 4'-PEG3-azide

Cat.No: T39806

Synonym: Pomalidomide 4'-PEG3-azide

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