Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T16659 |
Boc-NH-PEG2-C2-NH2
PROTAC Linker 13 |
Others | Others |
Boc-NH-PEG2-C2-NH2 (PROTAC Linker 13) is a PEG-based linker utilized for the synthesis of PROTACs. This chemical compound plays a crucial role in connecting the targeted protein and the E3 ubiquitin ligase for selective protein degradation[1]. | |||
T14184 |
Alkynyl myristic acid
tetradec-13-ynoic acid,13-Tetradecyn-1-oic acid,13-Tetradecynoic acid |
Others; PROTAC Linker | Others; PROTAC |
Alkynyl myristic acid (13-Tetradecyn-1-oic acid) 是一种基于烷基链的 PROTAC 接头。 | |||
T40031 |
Thalidomide-O-C6-NH2 hydrochloride
4-((6-aminohexyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride,萨力多胺-O-C6-氨基盐酸盐 |
E3 Ligase Ligand-Linker Conjugate | PROTAC |
Thalidomide-O-C6-NH2 hydrochloride (4-((6-aminohexyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride) 是一种合成的E3 连接酶配体 -linker 偶联物,用于 PROTAC dTAG-13 的合成。其中 dTAG-13 是一种 FKBP12F36V 和 BET 的降解剂。 | |||
T14012 | 2-(Azido-PEG2-amido)-1,3-propandiol | Others | Others |
2-(Azido-PEG2-amido)-13-propandiol is a Polyethylene glycol (PEG)-based PROTAC linker used for the synthesis of PROTACs[1]. | |||
T17897 |
cIAP1 Ligand-Linker Conjugates 13
E3 ligase Ligand-Linker Conjugates 43 |
Others | Others |
cIAP1 Ligand-Linker Conjugates 13, containing an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker, are utilized in the development of SNIPERs[1]. | |||
T14014 |
2-(Biotin-amido)-1,3-bis-(C1-PEG1-acid)
|
Others | Others |
2-(Biotin-amido)-13-bis(carboxylethoxy)propane is a polyethylene glycol (PEG)-based PROteolysis TArgeting Chimera (PROTAC) linker utilized in the synthesis of PROTACs[1]. | |||
T15870 |
m-PEG4-azide
13-Azido-2,5,8,11-tetraoxatridecane |
Others | Others |
m-PEG4-azide, also referred to as 13-Azido-2,5,8,11-tetraoxatridecane, functions as a PEG-based PROTAC linker suitable for PROTACs synthesis[1]. | |||
T18825 |
Thalidomide-O-C6-NH2
|
Others | Others |
Thalidomide-O-C6-NH2 is a synthesized E3 ligase ligand-linker conjugate used in the PROTAC dTAG-13, a degrader of FKBP12F36V and BET[1]. | |||
T36281 |
VH 032 amide-alkylC5-amine
VH 032 amide-alkylC5-amine |
||
Functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC research and development; incorporates an E3 ligase ligand plus an alkyl linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has been recently renamed. The previous name for this product was VH 032 - linker 13 PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license. | |||
T18824 |
Thalidomide-O-C6-NH2 TFA
|
Others | Others |
Thalidomide-O-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate used in the PROTAC dTAG-13, a degrader of FKBP12F36V and BET[1]. | |||
T18681 |
SJFα
|
Others; PROTACs | Others; PROTAC |
SJFα is a 13-atom linker PROTAC. SJFα degrades p38α with a DC50 of 7.16 nM, but is far less effective at degrading p38δ (DC50=299 nM) and does not degrade the other p38 isoforms (β and γ) at concentrations up to 2.5 μM[1]. |