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Cat. No. Product Name Target Signaling Pathways
T37329 PROTAC IDO1 Degrader-1

PROTAC IDO1 Degrader-1

PROTACs PROTAC
PROTAC IDO1 Degrader-1 is the first potent IDO1 (indoleamine 2,3-dioxygenase 1) degrader that hijacks IDO1 to CRBN E3 ligase to introduce IDO1 into UPS and eventually achieve ubiquitination and degradation (DC50=2.84 μM). PROTAC IDO1 Degrader-1 moderately improves the tumor-killing activity of H ER2 CAR-T cells[1]. PROTAC IDO1 Degrader-1 (compound 2c) (10 μM; 24 hours) notably decreases IDO1 level induced by IFN-γ[1].PROTAC IDO1 Degrader-1 and IFN-γ (5 ng/mL) are incubated with HeLa cells for 24...

化合物

PROTAC IDO1 Degrader-1
Cat.No: T37329
Synonym: PROTAC IDO1 Degrader-1
Target: PROTACs
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