Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T18599 |
PROTAC BRD4-binding moiety 1
|
Others | Others |
PROTAC BRD4-binding moiety 1 is a BRD4 ligand that binds to the cereblon ligand through a linker, enabling the formation of a PROTAC complex. This complex efficiently degrades BRD4[1]. | |||
T18601 |
Desmethyl-QCA276
PROTAC BRD4-binding moiety 4 |
Others | Others |
Desmethyl-QCA276, the QCA276-based moiety, binds to cereblon ligand via a linker to form PROTAC to degrade BET. QCA276 is a BET inhibitor with an IC50 of 10 nM, and with a Ki of 2.3 nM[1]. |