Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T74124 | PROTAC BRD4 Degrader-11 | ||
PROTACBRD4Degrader-11 (compound 9a) 是一种有效的由von Hippel-Lindau 配体和BRD4配体相连的PROTAC。PROTACBRD4Degrader-11 可与 STEAP1 和 CLL1 抗体偶联从而降解 PC3 前列腺癌细胞中的BRD4蛋白,DC50值分别为 0.23 nM 和 0.38 nM。 | |||
T36628 |
PROTAC BRD4 Degrader-8
PROTAC BRD4 Degrader-8 |
PROTACs | PROTAC |
PROTAC BRD4 Degrader-8 is a potent BRD4 inhibitor, with IC50s of 1.1 nM and 1.4 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader-8 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells[1]. PROTAC BRD4 Degrader-8 (compound 8; 6 days) inhibits the proliferation of PC3 prostate cancer cells, with an IC50 of 28 nM[1].PROTAC BRD4 Degrader-8 (4 h) suppresses MYC gene transcript in MV4-11 AML cells, with an IC50 of 11 nM[1].PROTAC BRD4 Degrader-8 (4 h) potently degra... | |||
T78647 |
PROTAC BRD4 Degrader-16
|
PROTACs | PROTAC |
PROTACBRD4Degrader-16是一种高效的PROTAC BRD4降解剂,具有对BRD4(BD1)和BRD4(BD2)分别为34.58 nM及40.23 nM的IC50值。该化合物有效抑制G2/M阶段细胞周期蛋白B1(Cyclin B1)的表达,并显著诱导MV-4-11细胞的细胞凋亡(apoptosis)。 | |||
T74270 |
PROTAC BRD4 Degrader-17
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PROTACBRD4 Degrader-17 (compound 13i),作为一种高效的 PROTACBRD4 降解剂,其 IC50 值分别为 29.54 nM(针对 BRD4(BD1))和 3.82 nM(针对 BRD4(BD2))。该化合物有效抑制 G2/M 相的细胞周期蛋白 B1 (Cyclin B1) 的表达,并在 MV-4-11 细胞中显著诱导细胞凋亡(apoptosis)。 |