Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T37012 |
(±)-PPCC oxalate
|
Others | Others |
(±)-PPCC (oxalate) 是 sigma-1 激动剂,能与 sigma-1 受体相互作用(Ki=1.5 nM)。(±)-PPCC (oxalate) 在有认知障碍的大鼠中具有抗遗忘作用,可以改善大鼠的认知能力。 | |||
T37013 |
(+/-)-PPCC oxalate
|
Others | Others |
Selective sigma (σ) receptor ligand. Displays high affinity for σ1; also binds at σ2 sites (Ki = 1.5 nM and 50.8 nM respectively). Selective over a range of receptor types including dopaminergic and muscarinic receptors, DAT and SERT. Prezzavento et al (2007) Novel sigma receptor ligands: synthesis and biological profile. J.Med.Chem. 50 951 PMID:17328523 |Prezzavento et al (2008) A new sigma ligand, (±)-PPCC, antagonizes kappa opioid receptor-mediated antinociceptive effect. Life Sci. 82 549 PMI... |