Cat. No. | Product Name | Target | Signaling Pathways |
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T73710 | PMX 205 Trifluoroacetate | ||
PMX 205 Trifluoroacetate 是一种有效的补体C5a 受体 (C5aR;CD88) 拮抗剂。 | |||
T35836 |
PMX-205 (trifluoroacetate salt)
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PMX-205 is a cyclic hexapeptide that acts as a potent antagonist of C5a receptor (C5aR; IC50= 31 nM).1It is orally active and blocks inflammatory signaling and symptoms in animal models of colitis and allergic asthma.2,3PMX-205 is also brain penetrant and reduces neuroinflammation and neurodegeneration in an animal model of Alzheimer's disease.4 1.March, D.R., Proctor, L.M., Stoermer, M.J., et al.Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Rela... | |||
T12506 |
PMX 205 Trifluoroacetate (514814-49-4 free base)
PMX 205 Trifluoroacetate |
Others | Others |
PMX 205 Trifluoroacetate is a potent complement antagonist of C5a receptor. |