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抑制剂 & 化合物

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重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T36143	10-Pyrene-PC
	10-Pyrene-PC is a substrate for all PLA2s with the exception of cPLA2 and PAF-AH. Upon phospholipid hydrolysis, 10-pyrenyldecanoic acid is produced from 10-pyrene-PC. The monomeric 10-pyrenyldecanoic acid exhibits fluorescence (excitation 345 nm, emission 395 nm), allowing quantitation of phospholipase activity.
T37580	Arachidonoyl thio-PC
	Arachidonoyl Thio-PC is a substrate for many phospholipase A2s (PLA2s) including sPLA2, cPLA2, and iPLA2. Cleavage of the sn-2 fatty acid by PLA2 results in generation of a free thiol which reacts with chromogenic reagents such as DTNB (Ellman's reagent) and DTP to allow quantitation of PLA2 activity. Isozyme-specific cPLA2 activity can be measured by excluding or inhibiting sPLA2 and iPLA2 activities in the assay.
T37121	1,2-bis(heptanoylthio) Glycerophosphocholine
	Diheptanoyl Thio-PC is a substrate for all phospholipase A2s (PLA2s) with the exception of cPLA2 and PAF-acetyl hydrolase (PAF-AH). Interaction of this compound with a PLA2 results in cleavage of the sn-2 fatty acid generating a free thiol on the lysophospholipid. This free thiol can be detected using chromogenic substrates such as DTNB (Ellman's reagent) and DTP.
T37331	Pyrrophenone
	The group IVA phospholipase A2 (PLA2), known as calcium-dependent cytosolic PLA2 (cPLA2), selectively releases arachidonic acid (AA) from membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins (PGs) and leukotrienes (LTs). Pyrrophenone inhibits cPLA2α with an IC50 of 4.2 nM in enzyme assays and potently blocks the release of AA and the production of PGE2 and LTC4 in cells (IC50 = 24, 25, and 14 nM, respectively). Its action is reversible and selective, as py...

化合物

Cat.No: T36143

Arachidonoyl thio-PC

Cat.No: T37580

1,2-bis(heptanoylthio) Glycerophosphocholine

Cat.No: T37121

Cat.No: T37331

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01705	PLA2G2A Protein, Human, Recombinant (His) PLAS1,phospholipase A2, group IIA (platele...	Human	HEK293 Cells
	PLA2G2A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.4 kDa and the accession number is A0A024RA96.

重组蛋白

PLA2G2A Protein, Human, Recombinant (His)

Cat.No: TMPY-01705

Species: Human

Expression System: HEK293 Cells

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