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Cat. No. Product Name Target Signaling Pathways
T3211 Midostaurin

米哚妥林,N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251,苯甲酰基十字孢碱

Others; PKC Chromatin/Epigenetic; Cytoskeletal Signaling; Others
Midostaurin (PKC412) 是一种多靶点蛋白激酶抑制剂,有抗肿瘤活性,对 PKCα/β/γ、Syk、Flk-1、Akt、PKA、c-Kit、c-Fgr、c-Src、FLT3、PDFRβ和VEGFR1/2的IC50值范围为 22 到500 nM 之间。
T12280 O-Desmethyl Midostaurin

CGP62221,O-Desmethyl PKC412

Others Others
O-Desmethyl Midostaurin is the active Midostaurin metabolite via cytochrome P450 liver enzyme metabolism.
T12036 Midostaurin-D5

PKC412-D5,CGP 41251-D5

Others Others
Midostaurin-D5 is a deuterium labeled Midostaurin.
T12610L 3-Hydroxy Midostaurin

CGP52421

FLT Angiogenesis; Tyrosine Kinase/Adaptors
3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412[1].
T19119 3-Hydroxy Midostaurin-D5

CGP52421-D5

Others Others
3-Hydroxy Midostaurin-D5 (CGP52421-D5) is a deuterium-labeled 3-Hydroxy Midostaurin which is a metabolite of PKC412. PKC412 effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation (IC50s: 132 nM and 9.8 μM in culture medium and plasma).

化合物

Midostaurin
Cat.No: T3211
Synonym: 米哚妥林,N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251,苯甲酰基十字孢碱
Target: Others, PKC
O-Desmethyl Midostaurin
Cat.No: T12280
Synonym: CGP62221,O-Desmethyl PKC412
Target: Others
Midostaurin-D5
Cat.No: T12036
Synonym: PKC412-D5,CGP 41251-D5
Target: Others
3-Hydroxy Midostaurin
Cat.No: T12610L
Synonym: CGP52421
Target: FLT
3-Hydroxy Midostaurin-D5
Cat.No: T19119
Synonym: CGP52421-D5
Target: Others
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