搜索结果

Search Results for " pbd dimer "

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T19560	SGD-1882 PBD dimer	Others	Others
	SGD-1882 is a agent of cytotoxic, DNA minor-groove crosslinking pyrrolobenzodiazepine (PBD) dimer, and acting as the payload for ADCs.
T11046	Dimethyl-SGD-1882 Dimethyl-PBD dimer	Others	Others
	Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly efficient DNA alkylating agent used as antibody-drug conjugate (ADC) cytotoxin. PBD Dimer is a DNA alkylating agent that inhibits DNA replication.
T18364	Tesirine MP-PEG8-VA-PABC-PBD Dimer	Others	Others
	MP-PEG8-VA-PABC-PBD Dimer is a drug-linker conjugates for ADC which is used in the treatment of several cancers. PBD Dimer is a DNA alkylating which inhibits DNA replication[1].
T84765	PBD dimer-2	Others	Others
	PBD dimer-2（化合物2c）是一种通过C8连接的吡咯苯二氮卓二聚体。该化合物能跨越一个额外碱基对，与5'-Pu-GA(T/A)TC-Py序列交联。PBD dimer-2作为有效载荷，在抗体-活性分子偶联物（ADC）中用于癌症研究具有重要价值。
T34628	SG3199 SG 3199,SG-3199	Others	Others
	SG3199 is a PBD dimer which binds in the minor groove of DNA, and forms covalent DNA interstrand cross-links in naked linear plasmid DNA. SG3199 is potently cytotoxic against a panel of human solid tumour and haematological cancer cell lines.
T77814	Tomaymycin DM	Others	Others
	Tomaymycin DM，一种Tomaymycin衍生的DNA烷化剂，作为肿瘤靶向抗体偶联活性分子(ADCs)有效载荷，是PBD单体。
T39458	DGN549-C DGN549-C	Others	Others
	DGN549-C is a novel compound featuring a cleavable ADC (antibody-drug conjugate) linker composed of valine-alanine (va) and a PBD (pyrrolobenzodiazepine) dimer. This compound possesses a unique DNA-alkylating cytotoxic payload, DGN549, which is utilized in the development of ADCs.
T9901A-026	Serclutamab talirine ABBV-321	Others	Others
	Serclutamab talirine (ABBV-321) 作为一种EGFR靶向抗体药物偶联物 (ADC)，由专门针对激活EGFR的抗体 (AM-1-ABT-806) 与吡咯苯二氮卓 (PBD) 二聚体构成，展现出显著的抗肿瘤活性。
T73469	SG2057 DRG16	Others	Others
	SG2057 (DRG16) 是一种含有戊二氧基键的 PBD 二聚体，该键选择性地结合DNA 小沟中的序列，形成 DNA 链间和链内交联加合物。SG2057 是一种高效抗肿瘤剂。
T77086	Mipasetamab uzoptirine	Others	Others
	Mipasetamab uzoptirine (ADCT-601) 是一种 AXL 靶向的抗体-活性分子偶联物(ADCs)。Mipasetamab uzoptirine 由人源化抗 AXL 抗体、可裂解连接子和有效的吡咯并苯二氮卓 (PBD) 二聚体细胞毒素 SG3199 组成。Mipasetamab uzoptirine 可用于癌症研究。