Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T61490 | P2X receptor-1 | ||
P2X receptor-1 是一种潜在的 P2X 受体抑制剂,用于治疗疼痛和炎症。 | |||
T71651 |
GSK1370319A
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GSK1370319A is a potent P2X7 antagonist (IC50 = 3.2 nM). GSK1370319A inhibits ATP-induced increase in IL-1β release and caspase 1 activation in lipopolysaccharide (LPS)-primed mixed glia by blocking assembly of the inflammasome in a pannexin 1-dependent manner. GSK1370319A also inhibits ATP-induced subregion-specific neuronal loss in hippocampal organotypic slice cultures, which is dependent on its ability to prevent inflammasome assembly in glia. Significantly, GSK1370319A attenuates age-relate... |