Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T71301 |
Opaganib HCl
|
||
ABC294640, also known as Opaganib, is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. Upon administration, ABC294640 competitively binds to and inhibits SK2, thereby preventing the phosphorylation of the pro-apoptotic amino alcohol sphingosine to sphingosine 1-phosphate (S1P), the lipid mediator that is pro-survival and critical for immunomodulation. This may eventually lead to the induction of apoptosis a... | |||
T71299 |
M-25
|
||
M-25 is a Smoothened antagonist and inhibitor of the Hedgehog pathway. |