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Cat. No. Product Name Target Signaling Pathways
T69932 OAT-1441

OAT-1441 is a hAMCase inhibitor.
T69931 MFH290

MFH290 is a novel cysteine (Cys)-directed covalent inhibitor of CDK12/13. MFH290 forms a covalent bond with Cys-1039 of CDK12, exhibits excellent kinome selectivity, inhibits the phosphorylation of serine-2 in the C-terminal domain (CTD) of RNA-polymerase II (Pol II), and reduces the expression of key DNA damage repair genes. Importantly, these effects were demonstrated to be CDK12-dependent as mutation of Cys-1039 rendered the kinase refractory to MFH290 and restored Pol II CTD phosphorylation ...

化合物

OAT-1441
Cat.No: T69932
Synonym:
Target:
MFH290
Cat.No: T69931
Synonym:
Target:
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