Cat. No. | Product Name | Target | Signaling Pathways |
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T70455 |
Nolpitantium besilate
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Nolpitantium besilate is a neurokinin-1 receptor antagonist. | |||
T70456 |
Nolpitantium Free Base
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Nolpitantium Free Base is a highly selective nonpeptide antagonist of neurokinin-1 (NK1) receptor. Nolpitantium potently, selectively and competitively inhibited substance P binding to NK1 receptors from various animal species, including humans. In vitro, it was a potent antagonist in functional assays for NK1 receptors such as [Sar9, Met(O2)11]substance P-induced endothelium-dependent relaxation of rabbit pulmonary artery and contraction of guinea-pig ileum. Up to 1 mkM, Nolpitantium had no eff... | |||
T26222 |
SR-140603
(R)-Nolpitantium Chloride |
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SR-140603, the less potent enantiomer of SR 140333, is used as the negative control. |