Cat. No. | Product Name | Target | Signaling Pathways |
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T13792 | Nampt-IN-3 | Others | Others |
Nampt-IN-3 simultaneously inhibit nicotinamide phosphoribosyltransferase (NAMPT) and HDAC (IC50s of 31 nM and 55 nM, respectively). | |||
T18477 |
NAMPT inhibitor-linker 1
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Others | Others |
NAMPT inhibitor-linker 1, a drug-linker conjugate for ADC, integrates an NAMPT inhibitor (as a payload) with a linker. In the formulation of ADC-3, it pairs with an anti-c-Kit monoclonal antibody, demonstrating strong efficacy against c-Kit expressing cell lines, specifically GIST-T1 and NCI-H526, where it exhibits IC50 values of <3 pM and 9 pM, respectively. | |||
T72623 |
Nampt activator-3
|
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NAMPTactivator-3 是一种 NAT 衍生物,是一种 NAMPT 激活剂,EC50为 2.6 μM,KD 为 132 nM。NAMPTactivator-3 有效保护培养细胞免受 FK866 介导的毒性。NAMPTactivator-3 在化疗引起的周围神经病变 (CIPN) 小鼠模型中表现出强大的神经保护功效,没有任何明显的毒性。 |