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Targets Recommended: Neurotensin Receptor

抑制剂 & 化合物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T78954	hNTS1R agonist-1	Neurotensin Receptor	GPCR/G Protein
	hNTS1R agonist-1 (Compound 10)为能穿透血脑屏障的hNTS1R全激动剂（Ki：6.9 nM）。它能提升帕金森病（PD）模型小鼠的运动能力及记忆。作为一种Neurotensin(8-13)类似物，hNTS1R agonist-1同时具有神经保护作用。
T16034	Meclinertant SR 48692	Others	Others
	Meclinertant is an effective, selective, nonpeptide, and orally active neurotensin receptor 1 (NTS1) antagonist. Meclinertant competitively antagonizes neurotensin-induced intracellular Ca2+ mobilization (pA2 : 8.13), in human colon carcinoma (HT-29) cell
T38807L	[Lys8, Lys9]-Neurotensin (8-13) acetate	Neurotensin Receptor	GPCR/G Protein
	[Lys8, Lys9]-Neurotensin (8-13) acetate 是一种神经降压素类似物，通过激活 G 蛋白偶联受体 NTS1 和 NTS2 发挥镇痛作用，hNTS1 和 hNTS2 受体的 Ki 值分别为 0.33 nM 和 0.95 nM。
T37529	TC NTR1 17
	Non-peptide neurotensin receptor 1 (NTS1) partial agonist (EC50 <15.6 nM and Emax = 63% of neurotensin response in Ca2+ mobilization assay). Exhibits over 50-fold selectivity for NTS1 over NTS2 and GPR35. Hershberger et al (2014) Imidazole-derived agonists for the neurotensin 1 receptor. Bioorg.Med.Chem.Lett. 24 262 PMID:24332089
T16358	NTRC-824	Others	Others
	NTRC-824 is >150-fold selectivity for NTS2 over NTS1 (Ki >30 μM). NTRC-824 is an effective, selective, and neurotensin-like nonpeptide neurotensin receptor type 2 (NTS2) antagonist (IC50: 38 nM and a Ki : 202 nM).
T38807	[Lys8, Lys9]-Neurotensin (8-13) JMV438,[Lys8, Lys9]-Neurotensin (8-13)
	[Lys8, Lys9]-Neurotensin (8-13) (JMV438) is a Neurotensin analog that elicits analgesic effects by activating the G protein-coupled receptors NTS1 and NTS2. The compound has K i values of 0.33 nM and 0.95 nM for hNTS1 and hNTS2 receptors, respectively.

化合物

hNTS1R agonist-1

Cat.No: T78954

Synonym:

Target: Neurotensin Receptor

Meclinertant

Cat.No: T16034

Synonym: SR 48692

Target: Others

[Lys8, Lys9]-Neurotensin (8-13) acetate

Cat.No: T38807L

Synonym:

Target: Neurotensin Receptor

[Lys8, Lys9]-Neurotensin (8-13)

Cat.No: T38807

Synonym: JMV438,[Lys8, Lys9]-Neurotensin (8-13)

Target:

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-01162	NTS1 Protein, Mouse, Recombinant (hFc) NTS1,NTRH,NN,NT,NTR1,NMN-1	Mouse	HEK293 Cells
	Crystal structures of neurotensin receptor subtype 1 (NTS1) allowed us to visualize the binding mode of the endogenous peptide hormone neurotensin and its pharmacologically active C-terminal fragment NT(8-13) within the orthosteric binding pocket of NTS1. NTS1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 42.9 kDa and the accession number is Q9D3P9.
TMPK-00982	NTS1 Protein, Cynomolgus, Recombinant (His) NTR1,NT,NTRR,NTRH,NTS1,NTS	Cynomolgus	HEK293 Cells
	Crystal structures of neurotensin receptor subtype 1 (NTS1) allowed us to visualize the binding mode of the endogenous peptide hormone neurotensin and its pharmacologically active C-terminal fragment NT(8-13) within the orthosteric binding pocket of NTS1. NTS1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 18.84 kDa and the accession number is Q2PG57.
TMPY-00561	Neurotensin Protein, Human, Recombinant (hFc) NMN-125,NTS1,NN,NT/N,neurotensin,...	Human	HEK293 Cells
	NTS (Neurotensin) is a Protein Coding gene. This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. NTS is a neuropeptide distributed in the central nervous and digestive systems. It belongs to the neurotensin family. NTS is an endogenous tridecapeptide of the central nervous system and the gastrointestinal tract of different mammalian species including the human. The human gene encoding neurotensin has previously been assigned to chromosome 12 but no regional locali...