Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPK-01030 |
LRRN1 Protein, Mouse, Recombinant (His)
Neuronal leucine-rich repeat protein 1,LRN,NLRR... |
Mouse | HEK293 Cells |
Lrrn1 is required for the formation of MHB--loss of function leads to a loss of the morphological constriction and loss of Fgf8. Cells overexpressing Lrrn1 violate the boundary and result in a loss of cell restriction between midbrain and hindbrain compartments. Lrrn1 also regulates the glycosyltransferase Lunatic Fringe, a modulator of Notch signalling, maintaining its expression in midbrain cells which is instrumental in MHB boundary formation. |