Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T78168 | NLRP3-IN-17 | NOD-like Receptor (NLR) | Immunology/Inflammation |
NLRP3-IN-17为一种高效、选择性且具有口服活性的NLRP3炎性体抑制剂,IC50为7 nM。该化合物在小鼠模型中显著抑制NLRP3依赖的IL-1β分泌,适用于慢性炎症疾病的研究。 | |||
T61709 | AMS-17 | ||
AMS-17 is a potent NLRP3 inhibitor, which effectively suppresses microglia activation both in vitro and in vivo. Additionally, AMS-17 exhibits inhibitory effects on various cytokines, such as caspase-1, TNF-α, IL-1β, and inducible nitric oxide synthase (iNOS), in N9 cells. Given these properties, AMS-17 holds promise as a valuable tool for investigating inflammation-associated neurological disorders [1]. | |||
T60868 | NF-κB-IN-4 | ||
NF-κB-IN-4 (化合物 17) 是有效的NF-κB 通路抑制剂,可透过血脑屏障(BBB)。NF-κB-IN-4 具有潜在的抗神经炎症活性,毒性低,可用于研究神经炎症相关疾病。NF-κB-IN-4 可阻断 IκBα 的活化及磷酸化,降低 NLRP3 的表达,从而抑制NF-κB 的激活。 |