Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T39524 |
Thalidomide-NH-PEG2-C2-NH-Boc
Thalidomide-NH-PEG2-C2-NH-Boc |
||
Thalidomide-NH-PEG2-C2-NH-Boc, a synthesized E3 ligase ligand-linker conjugate, combines the cereblon-targeting Thalidomide ligand with a PEG linker for the synthesis of dBRD9 (compound 6). This selective BRD9 probe PROTAC degrader is utilized in researching BAF complex biology. | |||
T14816 |
Bromoacetamido-C2-PEG2-NH-Boc
|
Others | Others |
Bromoacetamido-C2-PEG2-NH-Boc is a polyethylene glycol (PEG)-based linker with a bromoacetamido functional group and a tert-butoxycarbonyl (Boc) protecting group. It serves as an integral component in the synthesis of proteolysis-targeting chimeras (PROTACs), which are innovative compounds used for targeted protein degradation[1]. | |||
T16296 |
NH-bis(C2-PEG2-NH-Boc)
|
Others | Others |
NH-bis(C2-PEG2-NH-Boc) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells. | |||
T16299 |
NH-bis(PEG2-C2-Boc)
|
Others | Others |
NH-bis(PEG2-C2-Boc) is an alkyl/ether-based linker, utilized for the synthesis of PROTACs[1]. | |||
T16311 |
NH2-PEG2-C2-Boc
|
Others | Others |
NH2-PEG2-C2-Boc is a polyethylene glycol (PEG)-based PROTAC linker utilized for synthesizing PROTACs[1]. It serves as a non-cleavable 2-unit PEG linker for antibody-drug conjugates (ADCs) in their synthesis[2]. | |||
T14736 | Boc-NH-PEG2-C2-NHS ester | Others | Others |
Boc-NH-PEG2-C2-NHS ester is an alkyl/ether-derived PROTAC linker employed for the synthesis of PROTACs[1]. | |||
T16659 |
Boc-NH-PEG2-C2-NH2
PROTAC Linker 13 |
Others | Others |
Boc-NH-PEG2-C2-NH2 (PROTAC Linker 13) is a PEG-based linker utilized for the synthesis of PROTACs. This chemical compound plays a crucial role in connecting the targeted protein and the E3 ubiquitin ligase for selective protein degradation[1]. | |||
T18623 |
Boc-NH-PEG2-C2-amido-C4-acid
PROTAC Linker 30 |
Others | Others |
Boc-NH-PEG2-C2-amido-C4-acid (PROTAC Linker 30) is a polyethylene glycol (PEG)-based linker utilized for the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1]. | |||
T17906 |
Pomalidomide-amido-C4-amido-PEG2-C2-NH-Boc
E3 Ligase Ligand-Linker Conjugates 53,Cereblon Ligand-Linker Conjugates 20 |
Others | Others |
Pomalidomide-amido-C4-amido-PEG2-C2-NH-Boc is a novel synthesized conjugate compound functioning as an E3 ligase ligand-linker in PROTAC technology. This compound incorporates a Pomalidomide-derived cereblon ligand, which binds selectively to the E3 ligase cereblon, and a 2-unit PEG linker, which provides stability and flexibility to the conjugate. |