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Cat. No.	Product Name	Target	Signaling Pathways
T36705	Mitomycin A	Antibiotic	Microbiology/Virology
	Mitomycin A 是从链霉菌中提取出具有细胞毒性的抗生素，具有抗癌活性和抗肿瘤活性。Mitomycin A 可用于研究实体癌。
T32429	KW 2149 KT6149,KW2149,KW-2149
	KW 2149 is a compound derived from mitomycin C.
T26102	RM 49 RM49,RM-49
	RM 49 is a mitomycin C derivative that has antitumor activity in vitro.
T29487	7-N-(4-Hydroxyphenyl)mitomycin C
	7-N-(4-Hydroxyphenyl)mitomycin C is a bioactive chemical.
T80635	Gentisuric acid	Drug Metabolite	Metabolism
	Gentisuric Acid，作为Aspirin的代谢产物同时也是α-酰胺化单加氧酶（PAM）的底物，可抵御Mitomycin C导致的DNA损伤。
T68675	Porfiromycin
	Porfiromycin is a n N-methyl derivative of the antineoplastic antibiotic mitomycin C isolated from the bacterium Streptomyces ardus and other Streptomyces bacterial species. Bioreduced porfiromycin generates oxygen radicals and alkylates DNA, producing interstrand cross-links and single-strand breaks, thereby inhibiting DNA synthesis. Porfiromycin is preferentially toxic to hypoxic cells.
T36385	Ansatrienin A
	Ansatrienin A is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis. In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 64 nM), which is a measure of bone resorption, and pp60c-srcM kinase (IC50 = 100 nM). It also inhibits TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1; IC50 = 570 nM). Early in vitro studies showed that ansatrienin A potentiates the chemotherapeutic action of 5-fl...
T36650	Ansatrienin B
	Ansatrienin B is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis., In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 21 nM), which is a measure of bone resorption, and pp60c-src kinase (IC50 = 50 nM). It is an inhibitor of translation at the protein synthesis stage by specific inhibition of L-leucine incorporation (IC50 = 58 nM in A549 cells). It also inhibits TNF-α-induced expression of intercellul...

化合物

Cat.No: T36705

Target: Antibiotic

Cat.No: T32429

Synonym: KT6149,KW2149,KW-2149

Cat.No: T26102

Synonym: RM49,RM-49

7-N-(4-Hydroxyphenyl)mitomycin C

Cat.No: T29487

Gentisuric acid

Cat.No: T80635

Target: Drug Metabolite

Cat.No: T68675

Cat.No: T36385

Cat.No: T36650

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