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Cat. No.	Product Name	Target	Signaling Pathways
T3211	Midostaurin 米哚妥林,N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251,苯甲酰基十字孢碱	Others; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Others
	Midostaurin (PKC412) 是一种多靶点蛋白激酶抑制剂，有抗肿瘤活性，对 PKCα/β/γ、Syk、Flk-1、Akt、PKA、c-Kit、c-Fgr、c-Src、FLT3、PDFRβ和VEGFR1/2的IC50值范围为 22 到500 nM 之间。
T12036	Midostaurin-D5 PKC412-D5,CGP 41251-D5	Others	Others
	Midostaurin-D5 is a deuterium labeled Midostaurin.
T19119	3-Hydroxy Midostaurin-D5 CGP52421-D5	Others	Others
	3-Hydroxy Midostaurin-D5 (CGP52421-D5) is a deuterium-labeled 3-Hydroxy Midostaurin which is a metabolite of PKC412. PKC412 effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation (IC50s: 132 nM and 9.8 μM in culture medium and plasma).
T12610L	3-Hydroxy Midostaurin CGP52421	FLT	Angiogenesis; Tyrosine Kinase/Adaptors
	3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412[1].
T12280	O-Desmethyl Midostaurin CGP62221,O-Desmethyl PKC412	Others	Others
	O-Desmethyl Midostaurin is the active Midostaurin metabolite via cytochrome P450 liver enzyme metabolism.
T12610	(R)-3-Hydroxy Midostaurin (R)-CGP52421	Others	Others
	(R)-3-Hydroxy Midostaurin is a potent inhibitor of kinases,is a major metabolite of midostaurin undergoing by the hepatic CYP3A4 enzyme,has the potential for acute myeloid leukemia (AML).
T12791	(S)-3-Hydroxy Midostaurin (S)-CGP52421	Others	Others
	(S)-3-Hydroxy Midostaurin is a potent inhibitor of kinases(IC50 of <400 nM for 13 kinases (VEGFR-2, TRK-A, FLT3, et)).
TMIH-0404	O-Desmethyl Midostaurin-d5
	O-Desmethyl Midostaurin-d5 是 O-Desmethyl Midostaurin 的氘代化合物。
TMIH-0038	3 Hydroxy Midostaurin Epimer 1-d5 CGP52421 Epimer 1-d5
	3 Hydroxy Midostaurin Epimer 1-d5 是 3 Hydroxy Midostaurin Epimer 1 的氘代化合物。3 Hydroxy Midostaurin Epimer 1 的 CAS 号为 945260-14-0。
TMIH-0039	3 Hydroxy Midostaurin Epimer 2-d5 CGP52421 Epimer 2-d5
	3 Hydroxy Midostaurin Epimer 2-d5 是 3 Hydroxy Midostaurin Epimer 2 的氘代化合物。3 Hydroxy Midostaurin Epimer 2 的 CAS 号为 155848-20-7。