Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP2005 |
Kisspeptin-54(human)
Metastin (human) |
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Potent endogenous ligand of the kisspeptin receptor (KISS1, GPR54). Binds with high affinity to rat and human KISS1 receptors with Ki values of 1.80 and 1.45 nM respectively. Inhibits chemotaxis, invasion and metastasis of human melanomas and breast carci | |||
TP2156L |
TAK-683
|
Others | Others |
TAK-683 is an effective full KISS1 receptor agonist (IC50=170 pM). TAK-683 is a nonapeptide metastin analog, shows agonistic activities to KISS1R (EC50: 0.96 nM and 1.6 nM for human and rat, respectively). | |||
TP1467 |
KISS1-305
|
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KISS1-305, the Metastin/Kisspeptin analog, is a prototype peptide and a chemical probe. KISS1-305 has suboptimal KISS1R agonistic activity, and resists plasma protease degradation.KISS1-305 is a proto- type peptide that resists plasma protease degradation | |||
T75774 |
Kisspeptin-54(human) TFA
|
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Kisspeptin-54(human) TFA (Metastin(human) TFA) 是一种 Kisspeptin 受体 (KISS1,GPR54) 的内源性配体,以高亲和力结合大鼠和人类 GPR54受体,其Ki 值分别为 1.81 nM 和 1.45 nM。Kisspeptin-54(human) TFA 可抑制肿瘤转移并刺激促性腺激素分泌。 | |||
T76047 |
TAK-683 TFA
|
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TAK-683 TFA是一种高效的全KISS1R激动剂(IC50=170 pM),拥有较好的代谢稳定性,是九肽metastin的类似物,对KISS1R有激动效应,其对人和大鼠EC50值分别为0.96 nM和1.6 nM。TAK-683 TFA能够降低下丘脑GnRH水平,进而减少血浆FSH、LH、睾酮的浓度,显示出对激素依赖性前列腺癌研究的可能性。 | |||
T76048 |
TAK-683 acetate
|
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TAK-683 acetate是一种高效的KISS1R激动剂(IC50=170 pM),改善了代谢稳定性。作为九肽metastin的类似物,对人和大鼠的EC50值分别为0.96 nM和1.6 nM。该化合物通过消耗下丘脑GnRH,能够降低血浆FSH、LH、睾酮水平,展示了对研究激素依赖性前列腺癌的潜力。 |