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抑制剂 & 化合物

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天然产物

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Cat. No. Product Name Target Signaling Pathways
T8974 ML-211

Others Others
ML-211 是基于氨基甲酸酯的酰基蛋白硫酯酶1 / 溶血磷脂酶1 (IC50=17 nM) 和LYPLA2(IC50=30 nM) 的双重抑制剂。它能够抑制丝氨酸水解酶ABHD11 (IC50=10 nM),但在 20 个丝氨酸水解酶组合中,对 LYPLA 的选择性为 50 倍。
T36693 FD-211

FD-211 is a δ lactone originally isolated from M. lutea with anticancer activity.1 It is cytotoxic to adriamycin-susceptible P388, T-24, HeLa, A549, and HL-60 cancer cells (IC50s = 4, 0.5, 1, 1, and 0.2 μg/ml, respectively), as well as adriamycin-resistant HL-60/ADR cells (IC50 = 0.1 μg/ml). FD-211 also inhibits DNA, RNA, and protein synthesis in HeLa cells (IC50 = 1.25 μg/ml for all). |1. Nozawa, O., Okazaki, T., Sakai, N., et al. A novel bioactive δ lactone FD-211. Taxonomy, isolation and char...

化合物

ML-211
Cat.No: T8974
Synonym:
Target: Others
FD-211
Cat.No: T36693
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T35667 Napyradiomycin A1

Napyradiomycin A1

Napyradiomycin A1is a fungal metabolite originally isolated fromC. rubraand has diverse biological activities.1,2It is active againstS. aureus,M. luteus,B. anthracis,C. bovis, andM. smegmatis(MICs = 1.56-12.5 μg/ml).1Napyradiomycin A1is an estrogen receptor antagonist (IC50= 4.2 μM in rat uterine homogenates).2It also inhibits mitochondrial NADH:ubiquinone oxidoreductase (complex I) and succinate:ubiquinone oxidoreductase (complex II) activities in bovine heart homogenates (IC50s = 20 and 9.7 μM...

天然产物

Napyradiomycin A1
Cat.No: T35667
Synonym: Napyradiomycin A1
Target:
TargetMol Loading
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