Cat. No. | Product Name | Target | Signaling Pathways |
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T74860 | MAO-B-IN-21 | Monoamine Oxidase | Neuroscience |
MAO-B-IN-21是一种有效的MAO-B抑制剂,该化合物表现出抗氧化和抗Aβ聚集的活性。该化合物还可螯合金属离子,抗神经炎症(如NO、TNF-α),具有神经保护作用,并可穿透BBB。在Aβ1-42诱导的阿尔茨海默病小鼠模型中,MAO-B-IN-21显著改善了记忆与认知功能。 | |||
T36903 |
Rasagiline-13C3 (mesylate)
Rasagiline-13C3 (mesylate) |
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Rasagiline-13C3is intended for use as an internal standard for the quantification of rasagiline by GC- or LC-MS. Rasagiline is an inhibitor of monoamine oxidase B (MAO-B; IC50= 4.43 nM for the rat brain enzyme).1It is selective for MAO-B over MAO-A (IC50= 412 nM for the rat brain enzyme). It inhibits serum and NGF withdrawal-induced apoptosis of PC12 cells when used at concentrations ranging from 0.01 to 100 μM.2Rasagiline inhibits rat brain MAO-Bin vivo(ED50= 0.1 mg/kg).1It reduces cerebral ede... |