Cat. No. | Product Name | Target | Signaling Pathways |
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T61830 | MAO-B-IN-10 | ||
MAO-B-IN-10 (compound 4f) is a highly potent and selective inhibitor of MAO-B (monoamine oxidase-B). It effectively penetrates the blood-brain barrier and exhibits an IC50 of 5.3 μM. This compound demonstrates the ability to inhibit self-mediated Aβ (amyloid β) aggregation by 58.2% and disaggregate it by 43.3%. Thus, MAO-B-IN-10 holds promise for Alzheimer's disease research [1]. | |||
T60650 |
MAO-B-IN-13
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MAO-B-IN-13 (compound 12a) 是一种高效、可逆和血脑屏障(BBB)渗透性的MAO-B 抑制剂 (IC50 = 10 nM)。MAO-B-IN-13 显示出神经保护和抗氧化活性, 可用于研究帕金森病。 | |||
T78860 |
MAO-B-IN-24
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Monoamine Oxidase | Neuroscience |
MAO-B-IN-24(化合物11h)为针对MAO-B的选择性、可逆性竞争抑制剂,抑制常数(IC50)为1.60 μM。该化合物同样对MAO-A表现出一定抑制效果(22.42 μM),并在10 μM的浓度时分别降低了AChE和BChE的活性至54.58%及88.43%。 | |||
T37354 |
CAY10680
CAY10680 |
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CAY10680 is a dopamine-sparing, benzothiazinone compound that selectively inhibits both MAO-B activity (IC50 = 34.9 nM in human) and adenosine A2A receptors (Ki = 39.5 nM in human). It demonstrates significantly less potent inhibitory values for other adenosine receptor subtypes (Kis > 1 μM) and MAO-A (IC50 ≥ 10 μM). At 1-20 μM, CAY10680 has been shown to abolish cAMP accumulation in CHO cells transfected with adenosine A2A receptors. In the central nervous system adenosine A2A receptor expressi... |