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Cat. No. |
Product Name |
Target |
Signaling Pathways |
T36626
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Lys-CoA
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Selective p300 histone acetyltransferase (HAT) inhibitor (IC50 = 50-500 nM). Exhibits approximately 100-fold selectivity for p300 over PCAF (IC50 = 200 μM). Inhibits p300-dependent transcription. Active in vivo.
Lau et al (2000) HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF. Mol.Cell. 5 589 PMID:10882143 |Liu et al (2008) The structural basis of protein acetylation by the p300/CBP transcriptional coactivator. Nature. 451 846 PMID:18273021 |Burns et al (... |
T73951
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Lys-CoA TFA
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Lys-CoA TFA为选择性p300组蛋白乙酰转移酶(HAT)抑制剂,IC50值介于50-500 nM。其对p300的选择性超过PCAF 100倍,PCAF的IC50值为200 μM。此外,Lys-CoA TFA能够抑制依赖p300-HAT活性的转录激活。 |