Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5994 |
KPT-6566
2-[[4-[[[4-(叔丁基)苯基]磺酰基]亚氨基]-1-氧代-1,4-二氢-2-萘基]硫基]乙酸 |
Others | Others |
KPT-6566 是共价结合的脯氨酰异构酶PIN1选择性抑制剂,能够与 PIN1 的催化位点共价结合,抑制并降解PIN1,具有抗癌活性。它对PIN1 PPIase 结构域的IC50=640 nM,Ki=625.2 nM。 | |||
T67441 | Acetic acid, 2-[[4-[[[4-(1,1-dimethylethyl)phenyl]sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]- | ||
KPT-6566 is a covalent PIN1 inhibitor that selectively targets cancer cells by a dual mechanism of action. |