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Search Results for " influenza ha "

23

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T38719L	Influenza HA (110-119) acetate	Others	Others
	Influenza HA (110-119) acetate 是流感病毒血凝素的 110-119 片段，可刺激 Treg 细胞增殖。
TP1735L	Influenza HA 126-138 acetate Influenza HA 126-138 acetate(207349-63-1 free base)	Others	Others
	Influenza HA 126-138 acetate 是一种流感病毒血凝素 (HA) 肽乙酸盐，包含氨基酸 126-138。它诱导胸腺和外周 T 细胞凋亡。
T38719	Influenza HA (110-119)
	Influenza HA (110-119) refers to a specific fragment (110-119) derived from the hemagglutinin protein of the influenza virus. This fragment has the ability to induce the proliferation of Treg cells.
TP1517	Influenza HA (518-526) Influenza HA 518-526
	Influenza HA (518-526) is an immunodominant epitope in H2d mice after flu virus infection.
TP1735	Influenza HA (126-138) Influenza HA 126-138
	Influenza HA (126-138) is a peptide derived from the hemagglutinin (HA) protein of the influenza virus. It consists of amino acids 126-138 and has the ability to induce apoptosis in both thymic and peripheral T-cells.
TP1854	Influenza HA (307-319) Influenza HA 307-319
	Influenza Hemagglutinin is an HLA-DRB 0101-restricted epitope from influenza hemagglutinin (307-319).
TP1276	HA Peptide	Others	Others
	HA Peptide 是一种由九个氨基酸组成的多肽，来自于人类流感血凝素 (HA) 。它普遍用于细胞生物学和生物化学中分离，纯化，检测和追踪目标蛋白。
T9231	Mbx2329	Antiviral	Immunology/Inflammation
	MBX2329 是一种流感病毒抑制剂，能特异性地抑制血凝素介导的病毒进入，HIV/HA(H5) 的 IC90值为8.6 μM。它能够有效地抑制多种甲型流感病毒。
T8793	CBS1117	Influenza Virus	Microbiology/Virology
	CBS1117 是一种病毒进入抑制剂，对甲型流感病毒 A/Puerto Rico/8/34 的 IC50为 70 nM。它干扰血凝素介导的融合过程。
T28605	RO5487624 RO 5487624,RO-5487624
	RO5487624 is an inhibitor of Influenza A HA-Mediated Fusion.
T27983	MBX2546 MBX-2546,MBX 2546
	MBX2546 is an Influenza A Virus Fusion Inhibitor. MBX2546 binds to HA and inhibits HA-mediated membrane fusion. Both binding and stabilization of HA by MBX2546 are required for the inhibition of viral infection. Mutations in MBX2546-resistant influenza A/
T74614	PROTAC Hemagglutinin Degrader-1
	PROTACHemagglutinin Degrader-1 (Compound V3) 是一种有效的 PROTAC 流感病毒血凝素 (influenza hemagglutinin(HA)) 降解剂，降解中值浓度为 1.44 μM。PROTACHemagglutinin Degrader-1 具有广谱抗流感病毒活性。
T37466	CAY10766
	CAY10766 is an antiviral compound.1It inhibits entry of influenza virus-like particles pseudotyped with hemagglutinin A (HA) from H5N1 influenza A virus into A549 cells (EC50= 0.24 μM). CAY10766 (1 μM) reduces H1N1 and H5N1 influenza A viral titers in infected MDCK cells. It also exhibits synergy with oseltamivir carboxylate in MDCK cells infected with the influenza A reporter PR8-NS1-Gluc virus.
T62216	Influenza virus-IN-5
	Influenza virus-IN-5 (Compound 5f) 是一种流感病毒血球凝集素 (hemagglutinin (HA)) 抑制剂，能够作用于 A/H3N2 病毒 (EC50: 1 nM)。
T15625	JNJ4796	Others	Others
	JNJ4796 is an oral active fusion inhibitor of the influenza virus, by inhibiting hemagglutinin (HA)-mediated fusion to neutralizing the influenza A group 1 virus. JNJ4796 mimics the functionality of the broadly neutralizing antibodies (bnAbs).
T69398	LUN15104
	LUN15104 is a novel hemagglutinin (HA) protein inhibitor, inhibiting entry and replication of diverse influenza viruses via the HA protein, showing potent antiviral activity against diverse H1N1, H5N1, and H3N2 influenza viruses encoding HA proteins from both groups 1 and 2. This product has no formal name. For the convenience of scientific communication, we named it by combining its InChi Key (3 letters from the first letter of each section) with the last 5 digit of its CAS#) according to MedKo...
T79444	HA-IN-1	Influenza Virus	Microbiology/Virology
	HA-IN-1（compound 5g）是靶向血凝素（HA）胰蛋白酶切割位点的配体，表现出高亲和力。该化合物能够抑制HA介导的膜融合，并在体内有效降低肺部病毒滴度，展现其作为甲型流感病毒（IAV）抑制剂和抗流感药物的潜力。
T68413	CBS1194
	CBS1194 is a novel antiviral agent against influenza A virus (IAV), and is more specifically, a group 2 IAV fusion inhibitor. CBS1194 prevents membrane fusion of the virus through the inhibition of the conformational change of hemagglutinin (HA). CBS1194 causes steric hinderance that prevents the rearrangement of the HA that would normally be induced by low-pH, by fitting into the pocket by the fusion peptide.
T77094	Navivumab
	Navivumab (CT-P23)是针对甲型流感病毒(influenza A virus) HA血凝素的单克隆抗体。该药物通过结合HA2蛋白的茎融合结构域，能中和H1、H2、H5及H9型甲型流感病毒。
T81037	Tat-HA-NR2B9c
	Tat-HA-NR2B9 是一种包括HIV-1 Tat细胞膜转导结构域片段、流感病毒血凝素(HA)表位标签以及NR2B(NR2B9c) C端9个氨基酸的化学复合物。该化合物能够降低大鼠缺血性脑损伤的梗塞面积，同时促进神经功能的恢复。
T77158	Diridavumab
	Diridavumab为一种针对HA茎的单克隆抗体。它能稳定HA的融合前结构，阻断细胞膜与病毒膜在核内体内因pH变化引起的融合。此抗体主要用于H2流感病毒研究。
T74762	Influenza A virus-IN-8
	Influenza A virus-IN-8 (S5) 为一种大环肽，无细胞毒性，并作为甲型流感病毒 (IAV) 的有效抑制剂，显示出较好的蛋白酶稳定性。其对 H1 和 H5 变体的IC50值分别低至 6.7 nM 和 6.6 nM。此外，Influenza A virus-IN-8 能够与 HA 茎的一个保守区域结合，特别是对 H1 变体展现出 1.0 nM 的高亲和性Kd 值。
T77009	Firivumab
	Firivumab (CT-P22; CT120)是一种针对人类IgG1单克隆的抗甲型流感病毒血凝素（Anti-IAV HA）抗体。该抗体能有效中和多种亚型，包括H1N1、H5N1、H6N1、H6N2、H8N4、H8N8、H9N2和H12N7。研究发现，Firivumab在小鼠模型中对H1N1病毒展现出显著的保护效果。

化合物

Influenza HA (110-119) acetate

Cat.No: T38719L

Target: Others

Influenza HA 126-138 acetate

Cat.No: TP1735L

Synonym: Influenza HA 126-138 acetate(207349-63-1 free base)

Target: Others

Influenza HA (110-119)

Cat.No: T38719

Influenza HA (518-526)

Cat.No: TP1517

Synonym: Influenza HA 518-526

Influenza HA (126-138)

Cat.No: TP1735

Synonym: Influenza HA 126-138

Influenza HA (307-319)

Cat.No: TP1854

Synonym: Influenza HA 307-319

Cat.No: TP1276

Target: Others

Cat.No: T9231

Target: Antiviral

Cat.No: T8793

Target: Influenza Virus

Cat.No: T28605

Synonym: RO 5487624,RO-5487624

Cat.No: T27983

Synonym: MBX-2546,MBX 2546

PROTAC Hemagglutinin Degrader-1

Cat.No: T74614

Cat.No: T37466

Influenza virus-IN-5

Cat.No: T62216

Cat.No: T15625

Target: Others

Cat.No: T69398

Cat.No: T79444

Target: Influenza Virus

Cat.No: T68413

Cat.No: T77094

Cat.No: T81037

Cat.No: T77158

Influenza A virus-IN-8

Cat.No: T74762

Cat.No: T77009

Cat. No.	Product Name	Target	Signaling Pathways
T75743	HA Peptide TFA
	HA Peptide (TFA) 为源自人类流感血凝素 (HA) 的九氨基酸多肽，在细胞生物学与生物化学领域内广泛应用于目标蛋白的分离、纯化、检测及追踪。
T37272	9(S),12(S),13(S)-TriHOME
	9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble epoxide hydrolase-independent manner.1,59(S),12(S)13(S)-TriHOME inhibits antigen-induced β-hexosaminidase release from RBL-2H3 mast cells (IC50= 28.7 μg/ml).2It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50= 40.95 μM).3In vivo, 9(S),12(S),13(S)-TriHOME...

天然产物

Cat.No: T75743

9(S),12(S),13(S)-TriHOME

Cat.No: T37272

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