Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02240 |
STAT1 Protein, Human, Recombinant (His & GST)
IMD31A,IMD31B,IMD31C,STAT91,CANDF... |
Human | Baculovirus Insect Cells |
STAT1 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT1 can be activated by various ligands, including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. It is a signal transducer and transcription activator that mediates cellular responses to interferons (IFNs),... | |||
TMPU-00003 |
STAT2 Protein, Human, Recombinant (His)
|
Human | E. coli |
Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of... |