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Cat. No. | Product Name | Target | Signaling Pathways |
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T79385 |
PDE1-IN-5
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PDE1-IN-5 (Compound 10c) 是一种PDE1C选择性抑制剂,IC50为15 nM。该化合物显示出抗炎活性,能够抑制LPS诱导的iNOS、TNF-α、IL-1α、IL-1β和IL-6表达。在DSS诱导的结肠炎小鼠模型中,PDE1-IN-5对抗炎性肠病(IBD)表现出治疗潜力,并可用于IBD相关研究。 |
Cat. No. | Product Name | Species | Expression System |
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TMPK-01229 |
IL-19 Protein, Human, Recombinant (hFc)
NG.1,IL-10C,Interleukin-19,白介素,白细胞介素,MDA1,... |
Human | HEK293 Cells |
Interleukin-19 (IL-19) has been shown to be involved in coronary artery diseases and atherosclerosis, while its expression in myocardial infarction is poorly understood. In this study, the dynamic increase in circulating IL-19 in acute ST-segment elevation myocardial infarction (STEMI) patients was detected.IL-19 is correlated with the severity of acute myocardial infarction, which may be a new idea for the clinical treatment of myocardial infarction. | |||
TMPY-00493 |
IL-19 Protein, Human, Recombinant (His)
interleukin 19,Interleukin-19,IL-10C,NG.1,... |
Human | Baculovirus Insect Cells |
The molecular features at the IL19 locus may modestly alter the establishment of HIV-1 infection. Interleukin (IL) 19, IL-20, and IL-24 belong to the IL-10 cytokine family and have been identified to play a role in the regulation of epidermal functions and inflammation. The expression of IL19 in biopsies of patients with active ulcerative colitis was increased compared with patients with quiescent ulcerative colitis and that colitis was attenuated in IL-19-deficient mice. The disruption of the e... |