Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3162 |
IDE1
|
Others | Others |
IDE1 是定形内胚层诱导物,有用于器官移植等方面的潜力。 | |||
T62836 | Hit 1 | ||
Hit 1 是一种胰岛素降解酶 (IDE) 的激活剂 (EC50: 5.5 μM),能够降低刺激葡萄糖的胰岛素分泌。 | |||
T35802 |
ML-345
|
||
Insulin-degrading enzyme (IDE) is a thiol-sensitive zinc-metallopeptidase that acts as the major insulin-degrading protease in vivo, mediating the termination of insulin signaling. [1] In addition to regulating insulin action in diabetes pathogenesis, IDE plays a role in Varicella-Zoster virus infection and degradation of amyloid-β, a peptide implicated in Alzheimer's disease. ML-345 is a small molecule inhibitor that selectively targets cysteine819 in IDE with an EC50 value of 188 nM. [2] It de... |