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抑制剂 & 化合物

天然产物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T80707	α-Hemolysin (Staphylococcus aureus)
	α-Hemolysin (Staphylococcus aureus) 是一种由金黄色葡萄球菌分泌的毒力因子，具有破坏宿主细胞质膜的多肽特性。α-Hemolysin 绑定细胞表面后，通过其单体组装成同型七聚体预孔结构，并转变为成熟的跨膜孔，形成水通道。这一过程促使 K+ 和 Ca2+ 离子通过膜，触发靶细胞的坏死性死亡。
T76973	Tosatoxumab
	Tosatoxumab (AR-301; KBSA301) 为一种人源化免疫球蛋白G1类单克隆抗体，专一性地中和金黄色葡萄球菌α毒素(α-溶血素; Hla)，通过与该毒素N末端表位结合，防止其功能性毒素孔的寡聚化。此抗体对于金黄色葡萄球菌引起的肺炎，作为传统抗生素疗法的辅助，展现出被动免疫治疗的潜力。

化合物

α-Hemolysin (Staphylococcus aureus)

Cat. No.	Product Name	Target	Signaling Pathways
TN2151	Rhamnocitrin	Others	Others
	Rhamnocitrin 是一种分离自黄芪(沙源子)中的类黄酮，具有抗氧化，抗炎和抗动脉粥样硬化活性。它是 DPPH 的清除剂(IC50:28.38 mM)。
TN1204	2,3-Dehydrokievitone 2,3-脱氢维酮	Antifungal	Microbiology/Virology
	2,3-Dehydrokievitone 是一种从刺桐属植物 Erythrina sacleuxii 中提取的一种异黄酮，具有抗菌活性，可通过降低α-溶血素表达来对抗耐甲氧西林金黄色葡萄球菌感染。
T3891	Oroxylin A-7-O-glucuronide Oroxylin A Glucoronide,千层纸素A-7-0-Β-D-葡萄糖醛酸苷,Oroxyloside,Oroxylin A 7-O-beta-D-glucuronide	Others	Others
	Oroxylin A-7-O-glucuronide (Oroxylin A Glucoronide) 是一种类黄酮葡糖苷酸，提取自 Scutellaria baicalensis 干燥的根中，具有脯氨酰寡肽酶(POP)抑制作用。

天然产物

Synonym: 2,3-脱氢维酮

Target: Antifungal

Oroxylin A-7-O-glucuronide

Cat.No: T3891

Synonym: Oroxylin A Glucoronide,千层纸素A-7-0-Β-D-葡萄糖醛酸苷,Oroxyloside,Oroxylin A 7-O-beta-D-glucuronide

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-03534	Delta-hemolysin Protein, S. aureus, Recombinant (His & KSI) hld,Delta-hemolysin,Delta-toxin,Delta-lysin	Staphylococcus aureus	E. coli
	Lyses erythrocytes and many other mammalian cells. Delta-hemolysin Protein, S. aureus, Recombinant (His & KSI) is expressed in E. coli expression system with N-6xHis-KSI tag. The predicted molecular weight is 18.3 kDa and the accession number is P0A0M1.
TMPH-00031	Aerolysin Protein, Aeromonas sobria, Recombinant (His & Myc) Hemolysin	Aeromonas sobria	E. coli
	Secreted, cytolytic toxin that forms pores in host membranes after proteolytic removal of a C-terminal propeptide, leading to destruction of the membrane permeability barrier and cell death. The pores are formed by transmembrane beta-strands and are approximately 3 nm in diameter.
TMPH-03522	Alpha-hemolysin Protein, S. aureus, Recombinant (His) Alpha-toxin,Alpha-HL	Staphylococcus aureus	P. pastoris (Yeast)
	Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Inhibits host neutrophil chemotaxis to the lesion region (Probable). Heptamer oligomerization and pore formation is required for lytic activity.
TMPH-03523	Alpha-hemolysin Protein, S. aureus, Recombinant (His & SUMO) Alpha-HL,Alpha-toxin	Staphylococcus aureus	E. coli
	Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Inhibits host neutrophil chemotaxis to the lesion region (Probable). Heptamer oligomerization and pore formation is required for lytic activity.
TMPH-00636	Hemolysin E, chromosomal Protein, E. coli, Recombinant (His)	E. coli	E. coli
	Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells.
TMPH-03568	Phospholipase C Protein, S. aureus, Recombinant (His)	Staphylococcus aureus	P. pastoris (Yeast)
	Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine. Phospholipase C Protein, S. aureus, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 3...
TMPH-03562	Leukocidin-F subunit/LukF Protein, S. aureus, Recombinant (His & Myc & SUMO)	Staphylococcus aureus	E. coli
	Leukocidin causes cytotoxic changes in polymorphonuclear leukocytes. Gamma-hemolysin causes hemolysis in red blood cells. Leukocidin-F subunit/LukF Protein, S. aureus, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 54.0 kDa and the accession number is P31715.