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Targets Recommended: Neurokinin receptor

2

抑制剂 & 化合物

2

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T23316 SB 218795

Neurokinin receptor GPCR/G Protein; Neuroscience
SB 218795 是一种有效的特异性 NK3 拮抗剂,对 hNK3 的 Ki 为 13 nM,比 hNK2 和 hNK1 的特异性高约 90 倍和 7000 倍。
T6905 Netupitant

Ro 67-31898/000,奈妥吡坦,CID 6451149

Neurokinin receptor GPCR/G Protein; Neuroscience
Netupitant (CID 6451149) 是一种高效选择性、可口服的神经激肽 1 受体 (NK1) 拮抗剂,具有止吐作用,在 CHO 细胞中对 hNK1的 Ki 值为 0.95 nM。

化合物

SB 218795
Cat.No: T23316
Synonym:
Target: Neurokinin receptor
Netupitant
Cat.No: T6905
Synonym: Ro 67-31898/000,奈妥吡坦,CID 6451149
Target: Neurokinin receptor
Cat. No. Product Name Species Expression System
TMPY-05291 CD57/B3gat1 Protein, Human, Recombinant (mFc)

LEU7,NK1,beta-1,3-glucuronyltransferase

Human HEK293 Cells
B3GAT1 is the key enzyme during the biosynthesis of the carbohydrate epitope HNK-1, which is present on a number of cell adhesion molecules important in neurodevelopment. Saturating concentrations of rVAR2 inhibited downstream integrin signaling, which was mimicked by knockdown of the core chondroitin sulfate synthesis enzymes β-1,3-glucuronyltransferase 1 (B3GAT1) and chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CSGALNACT1).
TMPJ-00220 B3GAT1 Protein, Human, Recombinant (His)

beta-1,3-glucuronyltransferase 1 (glucuron...

Human HEK293 Cells
B3GAT1 is the key enzyme during the biosynthesis of the carbohydrate epitope HNK-1, which is present on a number of cell adhesion molecules important in neurodevelopment. It adds a glucuronic residue to the terminal lactosamine residue (Gal beta 14GlcNAc) of a glycoprotein or glycolipid, which can be further sulfated to become the HNK1 epitope, a unique trisaccharide structure, HSO3-3GlcA beta 1-3Gal beta 1-4GlcNAc. The enzyme activity was found to be enhanced in the presence of sphingomyelin an...

重组蛋白

CD57/B3gat1 Protein, Human, Recombinant (mFc)
Cat.No: TMPY-05291
Species: Human
Expression System: HEK293 Cells
B3GAT1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00220
Species: Human
Expression System: HEK293 Cells
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